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.Management Sciences
Category: General Pharmacology
The phase I reactions of drug metabolism include The following except_____________?
A. Hydolysis
B. Reduction
C. Oxidation
D. Conjugation
Hepatic first pass metabolism is important in____________?
A. Drugs given IM
B. Drugs taken orally
C. Drugs given IV
D. None of the above
Drug which crosses placental barrier is____________?
A. phenytoin
B. Diazepam
C. Corticosteroids
D. All of the above
A prodrug is____________?
A. The proto type member of a class of drugs
B. The oldest member of a class of drugs
C. An inactive drug that is transformed in the body to an active metabolite
D. A drug that is stored in body tissues and is then gradually released in the direction
During administration of NSAIDs in children, the most important of dose administration is______________?
A. Weight of the child
B. Age of child
C. Nature of the drug
D. Chronicity of pain
A drug A & B compared, all are true except____________?
A. 1 mg of A causes same effect of 3 mg of B, so A is more potent
B. 1 mg of A cause effect not even caused by maximum tolerated dose of B, so drug A is more efficacious
C. 1 mg of A cause effect not caused by 1 mg of B so A is more efficacious
D. Efficacy is not dose dependent
Elimination after 4 half lives in first order kinetics is____________?
A. 84%
B. 93%
C. 80.5%
D. 4.75%
The ratio of the median lethal dose of the median effective dose is the_____________?
A. Morbidity index
B. Moratality index
C. Anesthetic ratio
D. Therapeutic index
Majority of drugs are transported across the membrane by____________?
A. Passive diffusion
B. Active transport
C. Facilitated trasnsport
D. Filtration
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